https://www.boulter-lab.co.uk/home daily 1.0 2021-02-12 https://www.boulter-lab.co.uk/our-research-interests daily 0.75 2026-01-19 https://images.squarespace-cdn.com/content/v1/5fd232a7efdb9c4ec48e75df/1613129741769-Q514ULPSF5VJJJIZVEYM/STD_E18.5%2Bhigh%2B2.jpg Our Research Interests - How do ducts form and grow in early life? In the liver, bile ducts form from a group of cells known as hepatoblasts. To form a duct, hepatoblasts form a transient structure known as the ductal plate that further develops into the biliary tree. Using a combination of human genetics and transgenic animal models, we know that a small number of signals are necessary for bile duct cells (cholangiocytes) to form. What is not very clear is what happens to these cells once they have been generated and what signals drives them to form ducts. https://images.squarespace-cdn.com/content/v1/5fd232a7efdb9c4ec48e75df/4260ad30-7eba-4250-81a8-24bcf631ba47/MAX_182_hom_20x_n2.nd2+- Our Research Interests - What signals promote the repair of damaged ducts in the adult and where do they come from? Blocked or injured ducts can result in damage to the liver. Because of this, the liver has evolved a mechanism to make new ducts - but this leads to particular challenges as a new duct needs to connect to the biliary tree, be the correct length & thickness and also needs to serve the right part of the liver. We are investigating how duct cells re-enter a proliferative phase following injury and ask how these cells build a new duct in the adult and how these duct cells interact with their microenvironment. https://images.squarespace-cdn.com/content/v1/5fd232a7efdb9c4ec48e75df/1613138431190-TKMXLQWP2R6WCZ17R03E/MAX_848599%2Ba%2B1.jpg Our Research Interests - What is happening at the interface between duct regeneration and cancer? Patients with underlying bile duct disease are much more likely to develop bile duct cancer (cholangiocarcinoma). We want to understand how the regenerative microenvironment is used by early cancers to establish themselves in the liver and how they begin to grow. We hope that by understanding this process we will be able to prevent the transition from disease into cancer in these patients. https://www.boulter-lab.co.uk/join-us daily 0.75 2025-09-15 https://www.boulter-lab.co.uk/meet-the-lab-1 daily 0.75 2026-03-24 https://images.squarespace-cdn.com/content/v1/5fd232a7efdb9c4ec48e75df/fab55810-a80f-4ead-a91b-522b4f68d371/DSC_7164b.jpg Meet the lab Luke leads the Liver Growth and Cancer Lab https://images.squarespace-cdn.com/content/v1/5fd232a7efdb9c4ec48e75df/a7ff7c1c-9169-4bd4-927c-89d4711a113a/IMG_6176.jpg Meet the lab Scott investigates why patients develop liver cysts https://images.squarespace-cdn.com/content/v1/5fd232a7efdb9c4ec48e75df/b94a85e8-aca5-4d63-9872-3008e1bcf738/Image.jpeg Meet the lab Paula looks at how stromal cells control tumour growth https://images.squarespace-cdn.com/content/v1/5fd232a7efdb9c4ec48e75df/bb3fcd97-ae29-4954-b5ce-16d3653562f6/Maria+for+web.jpg Meet the lab - Make it stand out Maria maps the tissue features that drive bile duct cancer https://images.squarespace-cdn.com/content/v1/5fd232a7efdb9c4ec48e75df/330fa040-c814-4196-8280-abeb338c3ada/IMG_0138_Original.jpg Meet the lab Andrea supports our work on liver disease and cancer https://images.squarespace-cdn.com/content/v1/5fd232a7efdb9c4ec48e75df/7aede99b-0244-440e-a486-653a1a0e596f/Mairi.jpg Meet the lab Mairi is interested in how cysts form and grow in the adult liver https://images.squarespace-cdn.com/content/v1/5fd232a7efdb9c4ec48e75df/45e7cfb5-4b56-40c4-b6fc-1d99a119a402/IMG_9574.jpg Meet the lab Euan explores how cancer cells manipulate tissue mechanics to grow. https://images.squarespace-cdn.com/content/v1/5fd232a7efdb9c4ec48e75df/52b5b534-21b5-47fd-a4b9-2c885db32023/Photo+1.JPG Meet the lab Connor uses spatial -omics to study cholangiocarcinoma https://images.squarespace-cdn.com/content/v1/5fd232a7efdb9c4ec48e75df/489d5df2-46cf-4eb6-8fe8-676759207955/1000194216.jpg Meet the lab Jane is exploring the earliest moment of carcinogenesis https://www.boulter-lab.co.uk/our-papers-and-preprints daily 0.75 2021-07-05 https://images.squarespace-cdn.com/content/v1/5fd232a7efdb9c4ec48e75df/1609716267678-LED096ZWC19IYQRPLUCY/Picture13.png Our papers and preprints https://images.squarespace-cdn.com/content/v1/5fd232a7efdb9c4ec48e75df/1609716271780-VF61GBS6X916N3LB8KYS/Picture14.png Our papers and preprints https://images.squarespace-cdn.com/content/v1/5fd232a7efdb9c4ec48e75df/1609716271174-BSN62CC56WJTU8WE7YEH/Picture15.png Our papers and preprints https://images.squarespace-cdn.com/content/v1/5fd232a7efdb9c4ec48e75df/1609716266884-TAOTDMWNOZXXE3E9RDK9/Picture16.png Our papers and preprints https://images.squarespace-cdn.com/content/v1/5fd232a7efdb9c4ec48e75df/1609716271866-6RW6OAA0BGNSGB0SPXDK/Picture17.png Our papers and preprints https://images.squarespace-cdn.com/content/v1/5fd232a7efdb9c4ec48e75df/e2ae26ea-7154-4e81-9f48-18c58d2b4aec/SML+for+website.emf.jpg Our papers and preprints https://images.squarespace-cdn.com/content/v1/5fd232a7efdb9c4ec48e75df/433466ec-2726-490b-93a0-5e4eaba89e18/Cancer+Research+cover.png Our papers and preprints https://images.squarespace-cdn.com/content/v1/5fd232a7efdb9c4ec48e75df/eec0ac16-85a5-4719-919d-d34f16ff7f57/stm.2023.15.issue-713.largecover.jpg Our papers and preprints https://images.squarespace-cdn.com/content/v1/5fd232a7efdb9c4ec48e75df/e0d198a2-4490-445e-baf5-2d8dfaa0ed7b/Raab+et+al.png Our papers and preprints https://images.squarespace-cdn.com/content/v1/5fd232a7efdb9c4ec48e75df/7fb874fb-96eb-4f7a-85c0-737194d03355/Jarman+et+al.png Our papers and preprints